YES, you can! We switched to a Wordpress website (CasaMarAzulSanPancho.com) for our two houses in September 2016. We are thrilled.
Everything works with MyVR: calendar synching, credit card payments and deposit refunds, email alerts about inquiries from HomeAway/VRBO, writing and sending emails (custom and automated), synching with HomeAway/VRBO (we withdrew from Airbnb since it wasn't giving us quality inquiries), MyVR reports, etc.
We continue to receive superb support from MyVR.
To build our website, I hired a fantastic designer-developer team, and provided the images, videos and content. We worked together on design and navigation. They took care of building the site, all tech details, coordinated plugins with MyVR, and trained me on how to update content.
One of our goals from the beginning was to attract quality guests. This influenced how we furnished our houses and how we communicate what our area and houses offer. Our website is often the first impression, and we wanted prospective guests to feel "THIS is the house I want!"
It's all working, Only two inquirers have asked if we'd discount our rate. After politely describing the advantages our houses offer, each booked at full price within 24 hours. Guests have indeed been our ideal: they respect our property and house rules, are telling their friends, and rebooking.
If you'd like to know more, email me at Hola@CasaMarAzulSanPancho.com.